The last course to undertake in HSLP, “Leadership in Health Sciences 5”, kicked off on October 28, 2015. This course will challenge HSLP students with difficult tasks and force them to use and sophisticate all the skills included in HSLP graduation competencies. The course employs PBL (problem-based learning) as its key learning method, and is structured around cases which will be chosen carefully from important contemporary issues in medicine. Tasks will be formulated so that they are complex, difficult, and challenging, and require a well-thought out step-wise plan to solve. Each group will have a fixed tutor throughout the course who will monitor and intervene in groups’ problem solving as often as necessary, unlike in some other PBL, to ensure its depth and quality so that these PBL exercises pose enough challenges, make learners leave their comfort zones, and push them to the edge. Tutor will also assess individual student’s performance and give timely feedback. We believe that this course will prepare them for real-world problem solving that awaits them in future.